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Can Rectal Cancer Patients with Complete Response to Neoadjuvant Chemoradiotherapy Avoid Surgery?
Emad Mofid Nassif Rezkallah1, Benjamin Perakath1
1Department of General and Colorectal surgery, Hereford, County Hospital, Wye Valley NHS Trust, UK.
Journal of Medical Physics
|April 27, 2026
Summary
The "Watch and Wait" pathway is a safe option for rectal cancer patients with complete response after neoadjuvant therapy. Survival and disease-free survival rates showed no significant difference compared to surgery.
Area of Science:
- Oncology
- Surgical Oncology
- Radiotherapy
Background:
- Rectal cancer is a prevalent malignancy globally.
- Neoadjuvant chemoradiotherapy (nCRT) is standard for locally advanced rectal cancer.
- The
Purpose of the Study:
- To evaluate the feasibility of the
Main Methods:
- Retrospective review of 41 patients undergoing neoadjuvant therapy for rectal cancer.
- MRI restaging was performed, with results compared to surgical excision or 3-month follow-up.
- Minimum 2-year follow-up for efficacy assessment of the
Main Results:
- The
Conclusions:
- The

