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Plant-Derived Bioactive Compounds: Antioxidation, Autophagy, and Translational Applications in Skin Protection.

Liangyu Zhu1, Mengsha Li1, Dianwen Wei1

  • 1Department of Natural Products Function, Institute of Natural Resources and Ecology, Heilongjiang Academy of Sciences, Harbin 150040, China.

Current Issues in Molecular Biology
|April 27, 2026
PubMed
Summary
This summary is machine-generated.

Plant compounds protect skin from aging and hyperpigmentation by boosting antioxidation and autophagy. This review integrates their dual mechanisms for better understanding and application in skin health.

Keywords:
antioxidationautophagybifunctional ingredientsoxidative stressplant-derived bioactive compoundsskin protection mechanismstranslational applications

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Area of Science:

  • Dermatology and Cosmeceutical Science
  • Natural Product Chemistry
  • Molecular Biology

Background:

  • Oxidative stress from external factors accelerates skin aging and causes hyperpigmentation.
  • Plant-derived compounds offer natural, safe solutions for skin protection with defined mechanisms.
  • Current research lacks a unified understanding of how these compounds utilize both antioxidation and autophagy for skin benefits.

Purpose of the Study:

  • To review and integrate the dual cellular protective mechanisms (antioxidation and autophagy) of plant-derived bioactive compounds for skin health.
  • To establish a novel "component-pathway-efficacy" regulatory network for plant-based skin protection.
  • To bridge knowledge gaps in natural product research, skin biology, and translational molecular biology.

Main Methods:

  • Comprehensive literature search across PubMed, Web of Science, Scopus, and Wiley Online Library.
  • Targeted keyword retrieval to identify relevant studies.
  • Selection of 129 core studies published between 2021 and 2025 based on relevance, rigor, and impact.

Main Results:

  • Construction of a novel "antioxidation-autophagy" synergistic regulatory model for skin protection.
  • Establishment of a consolidated dual-mechanism framework detailing the "component-pathway-efficacy" axis.
  • Integration of fragmented knowledge regarding plant compounds' effects on skin.

Conclusions:

  • Plant-derived compounds possess dual mechanisms (antioxidation and autophagy) crucial for skin protection against aging and hyperpigmentation.
  • The proposed framework provides a theoretical basis for understanding the molecular logic of these compounds.
  • This integrated approach facilitates further mechanistic studies and translational applications in skin health and regenerative medicine.