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Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
Published on: February 9, 2024
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Infra-slow body-surface potentials show a group-level association with thyroid cancer
Bohan Deng1,2, Ruili Zhang3,4, Yuxuan Liu1
1College of Information Science and Electronic Engineering, Zhejiang University, Hangzhou 310027, China.
Journal of Zhejiang University. Science. B
|April 28, 2026
Summary
Infra-slow body-surface potential (BSP) energy in Band 1 (0.025-0.2 Hz) showed a group-level association with thyroid cancer. This finding was reproducible even after automated quality control and stricter artifact removal.
Area of Science:
- Endocrinology
- Biomedical Engineering
- Oncology
Background:
- Thyroid cancer presents with systemic endocrine and metabolic effects.
- Electrodermal activity research has primarily focused on frequencies above 0.5 Hz.
- Infra-slow skin potential abnormalities are linked to mood disorders.
Purpose of the Study:
- To investigate infra-slow body-surface potential (BSP) features for potential diagnostic insights in thyroid cancer.
- To determine if infra-slow electrodermal activity (0.025–0.2 Hz) provides reproducible group-level information.
- To assess the impact of artifact control on the reliability of infra-slow BSP features.
Main Methods:
- Analysis of infra-slow body-surface potential (BSP) in the 0.025–0.2 Hz range (Band 1).
- Evaluation of group-level statistical differences in Band 1 energy between thyroid cancer patients and controls.
- Application of automated quality control (QC) and stringent artifact removal techniques.
Main Results:
- A clear group-level association was found between Band 1 energy and thyroid cancer.
- The observed association remained significant after automated QC.
- The association persisted even with stricter artifact removal settings, indicating robustness.
Conclusions:
- Infra-slow body-surface potential (BSP) features in Band 1 demonstrate a reproducible group-level association with thyroid cancer.
- These findings suggest potential for infra-slow electrodermal activity as a biomarker in thyroid cancer diagnostics.
- Controlled artifact analysis enhances the reliability of infra-slow BSP findings.
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