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Updated: Apr 30, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Formate-Mediated EDA Complex-Enabled C(sp2)-X Bond Cleavage and Intramolecular C-H Arylation: Synthesis of Cyclic
Jiahong Sui1, Yang Fu1, Xianglin Zhong1
1School of Life Science and Engineering, School of Chemistry, Southwest Jiaotong University, Chengdu 610031, China.
Abstract:
An electron donor-acceptor (EDA) complex-promoted strategy has been developed for C(sp2)-X bond cleavage and intramolecular C(sp2)-C(sp2) bond construction, enabling efficient synthesis of cyclic amides, sulfonamides, and biaryl amides. DMSO and formate play pivotal roles, with CO2·- identified as the key aromatization species. This protocol not only allows access to various nitrogen-containing heterocyclic derivatives, including those bearing a six-membered phenanthridin-6(5H)-one core, six-membered sulfonamides, and seven-membered sulfonamides, but also significantly circumvents the limitations of traditional catalytic systems.
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