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Baicalein Alleviates Brain Tissue Injury in Rats with Posterior Circulation Ischemic Vertigo by Repressing The

Xinru Zhang1, Yanyan Ye2

  • 1Department of Neurology, The First People's Hospital of Lin'an District, Hangzhou, Hangzhou, Zhejiang 311300, China.

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Baicalein treatment improved brain tissue injury and vertigo symptoms in rats with posterior circulation ischemic vertigo (PCIV). It works by inhibiting the TLR4/NF-κB pathway, reducing inflammation and improving blood flow.

Keywords:
BaicaleinInflammationNuclear Factor-Kappa BToll-Like Receptor 4

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Biochemistry

Background:

  • Posterior circulation ischemic vertigo (PCIV) presents a clinical challenge with limited therapeutic options.
  • Baicalein, a flavonoid from Scutellaria baicalensis, exhibits known anti-inflammatory and neuroprotective effects.
  • The specific impact of baicalein on PCIV and its underlying mechanisms require elucidation.

Purpose of the Study:

  • To investigate the therapeutic potential of baicalein in a rat model of PCIV.
  • To explore the molecular mechanisms by which baicalein exerts its effects on brain tissue injury in PCIV.
  • To assess the role of the TLR4/NF-κB signaling pathway in baicalein's action.

Main Methods:

  • An experimental study involving 80 rats, divided into sham, PCIV, baicalein, TAK242 (a TLR4 inhibitor), and combination treatment groups.
  • Assessment of neurological function, vestibular nucleus blood flow, hemorheological parameters, and histopathological changes (HE and TUNEL staining).
  • Western blotting was employed to quantify the protein expression of TLR4, p-NF-κB p65, and p-IκBα.

Main Results:

  • Baicalein treatment significantly improved escape latency, vestibular nucleus blood flow, and hemorheological indices in PCIV rats.
  • Histological analysis revealed reduced neuronal apoptosis and partial restoration of brain structure in baicalein-treated groups.
  • Baicalein significantly downregulated the protein expression of TLR4, p-NF-κB p65, and p-IκBα, indicating inhibition of the TLR4/NF-κB pathway.

Conclusions:

  • Baicalein demonstrates significant efficacy in alleviating vertigo symptoms and mitigating brain tissue damage in PCIV.
  • The neuroprotective effects of baicalein are mediated, at least in part, by the inhibition of the TLR4/NF-κB signaling pathway.
  • Combined treatment with baicalein and a TLR4 inhibitor yielded more pronounced therapeutic benefits.