Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Helium Plasma Radiofrequency for Aesthetic Subdermal Treatment: A Systematic Review and Meta-Analysis.

Aesthetic surgery journal. Open forum·2026
Same author

The Potential Role of Topical Skincare Approaches After Glucagon-like Peptide-1 Receptor Agonist Use and Rapid Weight Loss.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same author

A Multicenter Prospective Study of Enhanced Viability Fat Transfer for Cosmetic Augmentation and Reconstruction of the Breast.

Plastic and reconstructive surgery·2026
Same author

Nonfacial Use of Injectable Poly-L-lactic Acid: Safety Data From a Multicenter Observational Study in the United States.

Aesthetic surgery journal. Open forum·2026
Same author

Cosmetic Medicine and Aesthetic Surgery Journal: The Beautiful Bond Between Noninvasive Aesthetic Medicine and Plastic Surgery.

Aesthetic surgery journal·2026
Same author

Characterization of Tissue Histology for Collagenase Clostridium Histolyticum-aaes: Results in Humans Following Abdominoplasty-An Exploratory Pilot Study.

Aesthetic surgery journal·2026
Same journal

Pilot Study: DermiSphere: A Novel Hydrogel with Collagen Microspheres Dermal Regeneration Template.

Plastic and reconstructive surgery. Global open·2026
Same journal

Algorithm for Surgical Management of Symptomatic Hand and Digital Neuromas.

Plastic and reconstructive surgery. Global open·2026
Same journal

Predictors of Matching into Plastic Surgery Residency Integrated and Independent Tracks: A Systematic Review.

Plastic and reconstructive surgery. Global open·2026
Same journal

Defining the Vascular Anomalies in Maffucci Syndrome: A Systematic Review.

Plastic and reconstructive surgery. Global open·2026
Same journal

Safety Evaluation of the RibXcar Technique Using the Piezotome: An Analysis of Surgical Complications.

Plastic and reconstructive surgery. Global open·2026
Same journal

Four Decades of the Anterolateral Thigh Flap: Celebrating a Milestone in Reconstructive Microsurgery.

Plastic and reconstructive surgery. Global open·2026
See all related articles
  1. Home
  3. Pilot Study: Repeated Utenpanium (rzl-012) Treatment For Submental Fat Reduction.
  1. Home
  3. Pilot Study: Repeated Utenpanium (rzl-012) Treatment For Submental Fat Reduction.

Related Experiment Video

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

741

Pilot Study: Repeated Utenpanium (RZL-012) Treatment for Submental Fat Reduction.

Sachin M Shridharani1, Brian S Biesman2, Racheli Gueta3

  • 1From the Aesthetic Plastic Surgery, LUXURGERY, New York, NY.

Plastic and Reconstructive Surgery. Global Open
|April 29, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Repeat Utenpanium (RZL-012) injections effectively reduced submental fat (SMF) in patients seeking further aesthetic improvement. This retreatment demonstrated superior results and high patient satisfaction with a favorable safety profile.

More Related Videos

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
08:22

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

Published on: October 7, 2017

9.6K
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

1.6K

Related Experiment Videos

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

741
Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
08:22

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

Published on: October 7, 2017

9.6K
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

1.6K

Area of Science:

  • Aesthetics
  • Dermatology
  • Pharmacology

Background:

  • Utenpanium (RZL-012) is a novel injectable cytolytic agent.
  • It is under development for aesthetic and therapeutic uses.
  • This study focuses on repeat treatment for submental fat (SMF) reduction.

Purpose of the Study:

  • To evaluate the safety and efficacy of repeat RZL-012 treatment for SMF reduction.
  • To assess outcomes in patients previously treated with RZL-012.
  • To determine patient satisfaction and safety following retreatment.

Main Methods:

  • An open-label phase 2 study was conducted.
  • Fifteen patients received a second RZL-012 treatment for SMF.
  • Patients were followed for over 84 days, with assessments using standardized tools and safety monitoring.

Main Results:

  • 100% of patients showed at least a 1-grade improvement in SMF appearance.
  • 47% achieved at least a 2-grade improvement, exceeding initial treatment results.
  • 80% of patients reported satisfaction with the outcomes, and adverse events were localized and consistent with prior studies.

Conclusions:

  • Repeat RZL-012 treatment offers additional SMF reduction benefits.
  • The retreatment shows a favorable safety and tolerability profile.
  • RZL-012 is a potential option for patients seeking further aesthetic enhancement for SMF.