Related Experiment Video
Updated: May 1, 2026

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
Published on: June 6, 2025
Advancing regulatory use of NAMs for Chemical Safety Assessment: Progress in Brazil
Antonio Anax Falcão de Oliveira1, Octavio Presgrave2, Cristiane Caldeira da Silva2
1Aima Toxicologia, São Paulo, Brazil.
Abstract:
Brazil has advanced its chemical regulatory framework with the enactment of Law No. 15,022/2024, which establishes the National Inventory of Chemical Substances, aligning the country with international chemical management systems. The law creates a structured system for the registration, prioritization, and management of industrial chemicals, explicitly promoting the use of non-animal New Approach Methodologies (NAMs) and restricting animal testing to a measure of last resort. The manuscript contextualizes this new legislation within Brazil's broader regulatory and capacity-building trajectory. Starting with the Arouca Law (Law No. 11,794/2008), which established the National Council for the Control of Animal Experimentation (CONCEA), Brazil has progressively strengthened its institutional framework through the creation of BraCVAM and RENAMA. These initiatives have expanded national expertise in NAM-based testing and directly supported Brazil's phased ban on animal testing for cosmetics, initiated in 2023 and fully implemented in 2025. Brazil's model adopts a simplified, uniform data requirement at the initial registration stage, deferring more extensive data generation to the risk assessment phase. This approach incentivizes early reliance on non-animal tools such as QSAR, read-across, PBPK modeling, and IATAs. The planned timeline toward 2027 provides a strategic window to define protection goals, build regulatory confidence, and harmonize Brazil's system with global best practices, fostering ethical innovation, improved chemical safety, and sustainable industrial development.
More Related Videos
04:55Testing of Nanoparticle Release from a Composite Containing Nanomaterial Using a Chamber System
Published on: November 22, 2016
16:02Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
Related Concept Videos
Drug Regulation
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
2° Amines to N-Nitrosamines: Reaction with NaNO2
Drug Control Governance: Regulatory Bodies and Their Impact
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions
Toxicity Testing in Animals