Emerging Role of Cryoneurolysis in Spasticity Management: A Narrative Review

Cryoneurolysis is a minimally invasive procedure, guided by ultrasound and electrical stimulation, that uses controlled freezing to manage spasticity by inducing reversible axonotmesis. It has shown promising outcomes in adult and pediatric populations, particularly for patients unresponsive to botulinum toxin. This review highlights the mechanism of action, clinical evidence, safety profile, and cost considerations of cryoneurolysis, highlighting its role as a valuable addition to the multimodal approach to spasticity management. Further studies are needed to refine technique parameters and better understand its long-term effects.