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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

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Microstructural Characterization of Breast Lesion Subtypes Using Time-Dependent Diffusion MRI: A Multicenter Study.

Yongjia Zeng¹, Yuan Guo², Zhidan Zhong²

¹Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China (Y.Z., Q.M.).

Academic Radiology

|April 30, 2026

Summary

This summary is machine-generated.

Time-dependent diffusion MRI (Td-dMRI) with oscillating gradient spin-echo (OGSE) shows promise in distinguishing benign from malignant breast lesions. Microstructural parameters derived from this technique may also help differentiate benign lesions from carcinoma in situ.

Keywords:

Breast neoplasms Oscillating gradient spin-echo Time-dependent diffusion MRI

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Area of Science:

Radiology
Biomedical Imaging
Oncology

Background:

Accurate breast lesion characterization is crucial for appropriate patient management.
Conventional MRI has limitations in differentiating certain breast lesion subtypes.
Novel diffusion MRI techniques offer potential for improved diagnostic accuracy.

Purpose of the Study:

To assess the diagnostic performance of microstructural parameters from time-dependent diffusion MRI (Td-dMRI) using oscillating gradient spin-echo (OGSE).
To evaluate the ability of Td-dMRI parameters to differentiate between benign and malignant breast lesions.
To explore the utility of these parameters in distinguishing benign lesions from carcinoma in situ.

Main Methods:

Patients with breast lesions underwent conventional and Td-dMRI (OGSE).
The IMPULSED model was used to extract microstructural parameters.
Area under the ROC curve and logistic regression analyses were employed for diagnostic performance evaluation.

Main Results:

Microstructural parameters, including cell density, were significantly associated with lesion differentiation.
Higher Vin and lower ADC_OGSEN1 independently predicted malignant lesions (AUC = 0.86).
Significant differences in cell density, Vin, and ADC_PGSE were found between benign lesions and carcinoma in situ.

Conclusions:

Td-dMRI with OGSE technology demonstrates potential for differentiating benign from malignant breast lesions.
Derived microstructural parameters may aid in distinguishing benign lesions from carcinoma in situ.
This advanced MRI technique could enhance breast lesion diagnosis.