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Systemic Oxidative and Nitrosative Stress in Benign Prostatic Hyperplasia.
Marek Biesiadecki1, Sabina Galiniak1, Krzysztof Balawender1
1Faculty of Medicine, University of Rzeszów, al. Tadeusza Rejtana 16C, 35-959 Rzeszów, Poland.
Antioxidants (Basel, Switzerland)
|May 4, 2026
Summary
Benign prostatic hyperplasia (BPH) involves significant oxidative and nitrosative stress. Research shows BPH patients have lower antioxidant capacity and altered tryptophan metabolism, suggesting redox imbalance plays a key role.
Area of Science:
- Urology
- Biochemistry
- Pathophysiology
Background:
- Benign prostatic hyperplasia (BPH) is an age-related condition.
- Chronic inflammation and redox imbalance are increasingly linked to BPH.
- The systemic oxidative and nitrosative profile in BPH requires further characterization.
Purpose of the Study:
- To investigate the systemic oxidative and nitrosative profile in men with BPH.
- To assess antioxidant status, lipid peroxidation, protein nitration, glycoxidation, and tryptophan metabolism in BPH patients compared to controls.
Main Methods:
- Cross-sectional study involving 47 BPH patients and 40 healthy controls.
- Analysis of fasting serum samples for various redox biomarkers.
- Assessment of antioxidant capacity, lipid peroxidation, protein nitration, glycoxidation, and tryptophan metabolism.
Main Results:
- BPH patients exhibited lower antioxidant capacity and thiol levels.
- Increased lipid peroxidation and protein nitration were observed in BPH patients.
- Marked alterations in tryptophan metabolism, including kynurenine pathway activation, were found.
Conclusions:
- Systemic oxidative and inflammatory mechanisms are implicated in BPH pathophysiology.
- Lipid peroxidation, nitrosative stress, and kynurenine pathway activation are independently associated with BPH.
- Further longitudinal studies are needed to confirm these findings.
Keywords:
benign prostatic hyperplasiakynurenine pathwaylipid peroxidationnitrosative stressoxidative stressMore Related Videos
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