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Systemic Oxidative and Nitrosative Stress in Benign Prostatic Hyperplasia.

Marek Biesiadecki1, Sabina Galiniak1, Krzysztof Balawender1

  • 1Faculty of Medicine, University of Rzeszów, al. Tadeusza Rejtana 16C, 35-959 Rzeszów, Poland.

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|May 4, 2026
PubMed
Summary

Benign prostatic hyperplasia (BPH) involves significant oxidative and nitrosative stress. Research shows BPH patients have lower antioxidant capacity and altered tryptophan metabolism, suggesting redox imbalance plays a key role.

Keywords:
benign prostatic hyperplasiakynurenine pathwaylipid peroxidationnitrosative stressoxidative stress

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Area of Science:

  • Urology
  • Biochemistry
  • Pathophysiology

Background:

  • Benign prostatic hyperplasia (BPH) is an age-related condition.
  • Chronic inflammation and redox imbalance are increasingly linked to BPH.
  • The systemic oxidative and nitrosative profile in BPH requires further characterization.

Purpose of the Study:

  • To investigate the systemic oxidative and nitrosative profile in men with BPH.
  • To assess antioxidant status, lipid peroxidation, protein nitration, glycoxidation, and tryptophan metabolism in BPH patients compared to controls.

Main Methods:

  • Cross-sectional study involving 47 BPH patients and 40 healthy controls.
  • Analysis of fasting serum samples for various redox biomarkers.
  • Assessment of antioxidant capacity, lipid peroxidation, protein nitration, glycoxidation, and tryptophan metabolism.

Main Results:

  • BPH patients exhibited lower antioxidant capacity and thiol levels.
  • Increased lipid peroxidation and protein nitration were observed in BPH patients.
  • Marked alterations in tryptophan metabolism, including kynurenine pathway activation, were found.

Conclusions:

  • Systemic oxidative and inflammatory mechanisms are implicated in BPH pathophysiology.
  • Lipid peroxidation, nitrosative stress, and kynurenine pathway activation are independently associated with BPH.
  • Further longitudinal studies are needed to confirm these findings.