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Association Between Gut Microbiota and Postoperative Delirium-A Scoping Review
Izabella Prządo1, Patrycja Patronik1, Łukasz Karaś1
1Faculty of Medicine, Collegium Medicum, University of Rzeszów, 35-310 Rzeszów, Poland.
Nutrients
|May 4, 2026
Summary
Postoperative delirium (POD) risk increases with gut microbiota disorders. Modulating gut bacteria may offer new strategies for preventing and treating POD in elderly patients.
Area of Science:
- Gastroenterology
- Neurology
- Geriatrics
Background:
- Postoperative delirium (POD) is a frequent complication, particularly in elderly patients.
- POD is linked to poorer outcomes, extended hospital stays, and diminished quality of life.
- Gut-brain axis dysfunction and altered gut microbiota composition are implicated in POD pathogenesis.
Purpose of the Study:
- To review the association between gut microbiota and the incidence of POD.
- To synthesize current evidence on the role of gut microbiota in POD development.
Main Methods:
- Systematic review conducted following JBI and PRISMA-ScR guidelines.
- Searched six databases for relevant publications.
- Included seven studies after independent assessment based on PCC criteria.
Main Results:
- Disruptions in gut microbiota composition and associated metabolic/immune alterations elevate POD risk.
- Specific bacteria and metabolites (e.g., SCFAs, indoles) can influence POD development.
- Evidence suggests a significant link between gut dysbiosis and increased POD incidence.
Conclusions:
- Gut microbiota dysbiosis is a significant risk factor for POD.
- Understanding these mechanisms may lead to novel therapeutic approaches.
- Targeting gut microbiota modulation offers potential for POD prevention and treatment.
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