Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sperm Structure and Semen Composition01:22

Sperm Structure and Semen Composition

16.5K
During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
16.5K
Spermatogenesis01:41

Spermatogenesis

91.0K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
91.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a Conceptual Implant Stability Index Framework for Computational Risk Assessment in Implant Dentistry.

Bioengineering (Basel, Switzerland)·2026
Same author

Advanced Biomaterials for Restorative Dentistry: From Biocompatibility to Bioactive and Smart Materials.

Bioengineering (Basel, Switzerland)·2026
Same author

Developmental Versus Chromosomal Competence in Endometriosis: A Stepwise IVF Outcome Analysis.

Medicina (Kaunas, Lithuania)·2026
Same author

Dental Anxiety in Pediatric Patients: Contemporary Assessment and Multimodal Management Strategies.

Children (Basel, Switzerland)·2026
Same author

A Predictive Bioengineering Model of Dental Implant Instability in Systemic Bone Disorders: A Periotest-Based Analysis.

Bioengineering (Basel, Switzerland)·2026
Same author

Artificial ovary systems for fertility preservation: Current advances, bioengineering strategies, and translational perspectives.

Reproductive biology·2026

Related Experiment Video

Updated: May 5, 2026

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
08:48

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

5.1K

Relationship Between Sperm DNA Fragmentation and Composite Morphological Indices: A Multivariable Analysis.

Veliscu Andreea Carp1, Liana Ștefan2,3, Petronela Naghi3

  • 1Department of Clinical Disciplines, University of Medicine and Pharmacy Carol Davila, Eroii Sanitari Boulevard, 050474 Bucharest, Romania.

Medicina (Kaunas, Lithuania)
|May 4, 2026
PubMed
Summary

Sperm DNA fragmentation (SDF) is not independently linked to sperm morphology indices in male infertility. Quantitative semen parameters, like sperm concentration, are more predictive of SDF, suggesting complementary diagnostic roles for morphology and DNA integrity tests.

Keywords:
assisted reproductive technologygenomic integritymale infertilitysemen analysissperm DNA fragmentationsperm morphologyspermatogenesisteratozoospermia index

More Related Videos

U-Shaped Horizontal Swimming Technique for Preparing High-Quality Sperm with Low DNA Fragmentation Index
09:16

U-Shaped Horizontal Swimming Technique for Preparing High-Quality Sperm with Low DNA Fragmentation Index

Published on: March 28, 2025

807
Fluorimetric Techniques for the Assessment of Sperm Membranes
08:58

Fluorimetric Techniques for the Assessment of Sperm Membranes

Published on: November 28, 2018

13.6K

Related Experiment Videos

Last Updated: May 5, 2026

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
08:48

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

5.1K
U-Shaped Horizontal Swimming Technique for Preparing High-Quality Sperm with Low DNA Fragmentation Index
09:16

U-Shaped Horizontal Swimming Technique for Preparing High-Quality Sperm with Low DNA Fragmentation Index

Published on: March 28, 2025

807
Fluorimetric Techniques for the Assessment of Sperm Membranes
08:58

Fluorimetric Techniques for the Assessment of Sperm Membranes

Published on: November 28, 2018

13.6K

Area of Science:

  • Andrology
  • Reproductive Medicine
  • Genomic Stability

Background:

  • Sperm DNA fragmentation (SDF) is a marker of genomic instability in male infertility.
  • The relationship between sperm morphology and SDF is not fully understood.
  • Composite morphological indices may reflect spermatogenic dysfunction.

Purpose of the Study:

  • To evaluate the association between post-swim-up SDF and composite sperm morphology indices from raw semen.
  • To analyze these relationships using multivariable models adjusted for conventional semen parameters.

Main Methods:

  • Observational study of 183 semen samples from men undergoing fertility evaluation.
  • SDF assessed via sperm chromatin dispersion (SCD) assay post-swim-up.
  • Morphology evaluated using WHO criteria; Teratozoospermia Index (TZI), Sperm Deformity Index (SDI), and Multiple Anomalies Index (MAI) calculated.

Main Results:

  • No independent association found between composite morphological indices and SDF after adjusting for sperm concentration and progressive motility.
  • Sperm concentration showed a significant inverse association with SDF.
  • Distributional analyses indicated heterogeneity in the co-occurrence of morphological defects and DNA fragmentation.

Conclusions:

  • Composite sperm morphology indices do not independently predict SDF when quantitative parameters are considered.
  • Sperm morphology and SDF may represent complementary aspects of male infertility.
  • SDF testing offers additional diagnostic information beyond morphology, especially for assisted reproduction.