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Related Experiment Video

Updated: May 5, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
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Solid-State Synthesis Based on Natural Leucomisine.

Sergazy Adekenov1, Asel Amanzhan1, Dmitriy Savchenko1

  • 1JSC «Research and Production Center «Phytochemistry», M. Gazaliev St., Building 4, Karaganda 100009, Kazakhstan.

Molecules (Basel, Switzerland)
|May 4, 2026
PubMed
Summary
This summary is machine-generated.

This study enhances leucomisine

Keywords:
disodium glycyrrhizinateleucomisinesolid dispersionsolubility

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Area of Science:

  • Pharmacology and Phytochemistry
  • Materials Science
  • Drug Delivery Systems

Background:

  • Leucomisine, a sesquiterpene γ-lactone from Artemisia leucodes, possesses valuable therapeutic properties.
  • Its pharmaceutical application is hindered by poor aqueous solubility and low bioavailability.
  • Developing strategies to improve leucomisine's solubility is crucial for its medicinal use.

Purpose of the Study:

  • To investigate the solid-state synthesis of leucomisine using disodium glycyrrhizinate as a carrier.
  • To evaluate the impact of different synthesis methods on leucomisine's aqueous solubility and dissolution rate.
  • To elucidate the mechanisms behind solubility enhancement.

Main Methods:

  • Solid-state synthesis of leucomisine-disodium glycyrrhizinate complexes via solvent removal, simple mixing, and mixture heating.
  • Physicochemical characterization using visible-range spectrophotometry, microcrystalloscopy, optical property analysis, and X-ray phase analysis.
  • Quantification of solubility and dissolution rate improvements.

Main Results:

  • Synthesized solid dispersions demonstrated a 7-19-fold increase in leucomisine solubility.
  • Dissolution rates were significantly enhanced, showing a 36-100-fold increase.
  • The "simple mixing" method yielded the most substantial improvements in dissolution.

Conclusions:

  • Solid-state synthesis effectively enhances leucomisine's aqueous solubility and dissolution rate.
  • Mechanisms include loss of crystallinity, micronization, carrier-mediated solubilization, and colloidal solution formation.
  • Disodium glycyrrhizinate is a promising carrier for improving leucomisine's bioavailability.