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Related Experiment Video

Updated: May 5, 2026

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
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Asymmetric Osteitis and Pustulosis.

Maria D Pascoal1,2, Ana C Silva3

  • 1Serviço de Reumatologia, Unidade Local de Saúde da Região de Aveiro.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
|May 4, 2026
PubMed
Summary
This summary is machine-generated.

A patient initially diagnosed with psoriatic arthritis was later diagnosed with Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) syndrome after developing new symptoms. This case highlights the importance of reassessing diagnoses when new clinical features emerge.

Keywords:
SAPHOosteitispustulosis

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Area of Science:

  • Rheumatology
  • Dermatology
  • Orthopedics

Background:

  • Psoriatic arthritis can present with diverse symptoms.
  • Some patients may experience diagnostic challenges and treatment resistance.

Purpose of the Study:

  • To present a case study of a patient initially diagnosed with psoriatic arthritis.
  • To illustrate the diagnostic evolution towards Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) syndrome.

Main Methods:

  • Clinical case review.
  • Analysis of patient history, symptoms, and imaging findings.
  • Magnetic Resonance Imaging (MRI) for osteitis assessment.

Main Results:

  • The patient presented with inflammatory lumbosacral pain and palm/sole pustules.
  • MRI revealed changes consistent with osteitis.
  • A revised diagnosis of SAPHO syndrome was established.

Conclusions:

  • SAPHO syndrome should be considered in patients with inflammatory conditions and characteristic dermatological and skeletal findings.
  • Diagnostic reassessment is crucial for complex cases initially presumed to be psoriatic arthritis.