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Related Experiment Video

Updated: May 5, 2026

Fabrication and Characterization of Layer-By-Layer Janus Base Nano-Matrix to Promote Cartilage Regeneration
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Polyurethane-Based Biomaterials for Fibrocartilage Repair: Chemistry, Structure-Function Design, and Applications.

Jinfeng Hu1, Xinzhao Xu2, Songsong Zhu1,3

  • 1State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

ACS Applied Materials & Interfaces
|May 4, 2026
PubMed
Summary
This summary is machine-generated.

Polyurethane (PU) biomaterials offer versatile solutions for repairing fibrocartilage injuries in joints like the meniscus and TMJ disc. This review details PU strategies to improve mechanical and biological performance for better tissue regeneration.

Keywords:
biomaterialschemical modificationfibrocartilage repairfunctionalizationpolyurethane

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Orthopedics

Background:

  • Fibrocartilage tissues (meniscus, annulus fibrosus, TMJ disc) possess unique mechanical roles but limited self-repair capabilities.
  • Existing clinical treatments for fibrocartilage damage often yield suboptimal functional restoration and durability.
  • Polyurethane (PU)-based biomaterials show potential due to their tunable properties and biocompatibility.

Purpose of the Study:

  • To systematically review polyurethane (PU)-based strategies for fibrocartilage repair.
  • To highlight how PU chemistry and design modifications enhance mechanical, degradative, and biological performance.
  • To guide future research and clinical translation of PU biomaterials for fibrocartilage regeneration.

Main Methods:

  • Systematic review of literature on PU biomaterials for fibrocartilage repair.
  • Analysis of PU composition, structure, and design modifications.
  • Evaluation of PU-based implants in meniscus, annulus fibrosus (AF), and temporomandibular joint (TMJ) disc applications.

Main Results:

  • PU biomaterials can be chemically and structurally modified to achieve desired mechanical, degradative, and biological properties.
  • Recent advances demonstrate PU-based implants' potential for improving fibrocartilage repair outcomes.
  • Correlation established between material design, scaffold architecture, and functional performance.

Conclusions:

  • Polyurethane biomaterials represent a promising platform for developing advanced therapies for fibrocartilage injuries.
  • Tailoring PU properties is crucial for optimizing tissue integration and functional recovery.
  • Further research and clinical translation are needed to fully realize the potential of PU-based fibrocartilage repair strategies.