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Updated: May 5, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Chest Wall Hibernoma With Intense 18 F-FDG Uptake on PET/CT Mimicking Malignant Pleural Mesothelioma
Reina Shimotsu1, Yoko Karube2, Masashi Nakadate3
1Department of Radiology, Kashiwa Municipal Hospital, Chiba.
Abstract:
A man in his 60s with asbestos exposure and pleural plaques was incidentally found to have a chest wall mass on computed tomography (CT). Positron emission tomography/CT (PET/CT) demonstrated intense 18 F-fluorodeoxyglucose (FDG) uptake, raising concern for malignancy, including malignant pleural mesothelioma. CT and magnetic resonance imaging (MRI), however, showed a predominantly fat-containing lesion, suggesting hibernoma. Video-assisted thoracoscopic resection was performed, and histopathology confirmed hibernoma. Recognition of macroscopic fat on CT/MRI is essential to avoid misdiagnosis of FDG-avid benign lipomatous tumors.
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