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Related Experiment Video

Updated: May 6, 2026

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
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Identifying Key Pathogenic Mechanisms in Recurrent Glioblastoma Through Bioinformatics Analysis.

Xuan Rong1, Mingyang Han1, Luhao Bao1

  • 1Department of Neurosurgery, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong 518000, China.

Current Medicinal Chemistry
|May 5, 2026
PubMed
Summary

This study identifies Synaptotagmin 1 (SYT1) as a key gene in recurrent glioblastoma, highlighting its upstream microRNAs as potential biomarkers and therapeutic targets. Several repurposable drugs were also nominated for glioblastoma recurrence.

Keywords:
Glioblastomakey genesmiRNA-mRNA regulatory networksoncogenesisprognosisrecurrent glioblastomatherapeutic targets

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Area of Science:

  • Neuro-oncology
  • Genomics
  • Bioinformatics

Background:

  • Glioblastoma frequently recurs despite aggressive treatments.
  • Identifying molecular drivers of recurrence is crucial for improving patient outcomes.

Purpose of the Study:

  • To identify key genes, microRNAs (miRNAs), and mRNA regulatory networks in recurrent glioblastoma.
  • To nominate potential repurposable drugs for treating glioblastoma recurrence.

Main Methods:

  • Differential gene expression analysis of primary vs. recurrent glioblastoma.
  • Construction of protein-protein interaction networks and miRNA-mRNA interaction networks.
  • Utilized Connectivity Map (CMap) for drug repurposing and Kaplan-Meier analysis for survival outcomes.

Main Results:

  • Identified 201 differentially expressed genes (DEGs) and 10 hub genes.
  • Synaptotagmin 1 (SYT1) was identified as a hub gene, targeted by 12 miRNAs, with elevated expression linked to poorer survival.
  • Five compounds (levamisole, chlorzoxazone, ranitidine, atovaquone, chrysin) were nominated as potential therapeutics.

Conclusions:

  • SYT1 and its upstream miRNAs are potential biomarkers and therapeutic targets for recurrent glioblastoma.
  • Repurposable compounds warrant experimental validation for glioblastoma treatment.
  • Findings provide a foundation for personalized glioblastoma therapies.