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Diabetic Foot Ulcer

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...

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Updated: May 6, 2026

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

Triple-Responsive Hydrogel Integrating Polyphenol-Metal Activity for Infected Diabetic Wound Therapy.

Haibo Mu¹, Hua Liang¹, Liangliang Hu¹

¹College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.

ACS Applied Materials & Interfaces

|May 5, 2026

Summary

This summary is machine-generated.

A novel hydrogel dressing effectively treats infected diabetic wounds by combating bacteria, reducing oxidative stress, and promoting tissue repair. This innovative material offers a promising solution for complex wound healing challenges.

Keywords:

ROS scavenging Schiff base boronate ester carboxymethyl chitosan chondroitin sulfate diabetic wound healing photothermal antibacterial therapy triple-responsive hydrogel

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Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

Area of Science:

Biomaterials Science
Regenerative Medicine
Wound Healing

Background:

Infected diabetic wounds present complex challenges due to infection, oxidative stress, inflammation, and poor blood vessel formation.
Current treatments often struggle to address the multifaceted nature of these wounds effectively.

Purpose of the Study:

To develop a triple-responsive, injectable, adhesive, and self-healing hydrogel (RCGel) for dynamic regulation of the diabetic wound microenvironment.
To promote efficient tissue regeneration in infected diabetic wounds.

Main Methods:

RCGel synthesized via Schiff-base and boronate-ester cross-linking, incorporating rosmarinic acid-cerium nanoparticles.
Evaluated ROS-scavenging, photothermal antibacterial efficacy against MRSA and P. aeruginosa.
Assessed in vitro cytocompatibility, ROS reduction, macrophage polarization, and angiogenesis.
Tested in vivo wound closure, infection/inflammation suppression, neovascularization, and tissue remodeling in diabetic models.

Main Results:

RCGel demonstrated potent ROS-scavenging and effective photothermal antibacterial activity.
In vitro studies showed good cytocompatibility, reduced ROS, M2 macrophage polarization, and enhanced angiogenesis.
In vivo, RCGel accelerated wound closure, reduced infection and inflammation, and promoted tissue regeneration in diabetic models without toxicity.

Conclusions:

RCGel acts as a microenvironment-adaptive multifunctional dressing with antibacterial, antioxidative, immunomodulatory, and pro-regenerative properties.
This hydrogel offers a promising therapeutic strategy for treating infected diabetic wounds.