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Updated: May 8, 2026
Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model
Published on: June 27, 2018
Regulation on the Electrospinnability and Mechanical Property of Bioelastomers for Small-Diameter Vascular Grafts
Qing Tang1, Jiaxin Guo1, Xinyue Zhang2
1Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Abstract:
Electrospun elastic scaffolds are promising for small-diameter vascular grafts, but balancing electrospinnability with native-like mechanical properties remains challenging. To address this, various ABA (PCL-b-PMCL-b-PCL) and BAB (PMCL-b-PCL-b-PMCL) elastomers were synthesized. It was revealed that rapid crystallization promoted uniform, bead-free fibers, and ABA-type copolymers exhibited better elastic recovery than BAB types. To optimize both the electrospinnability and mechanics, the ABA3 copolymer was selected to fabricate grafts. It was demonstrated that the grafts had a tensile strength of 3.99 ± 0.15 MPa and a high compliance of 9.62 ± 0.85%/100 mmHg, perfectly matching those of native blood vessels. Additionally, the grafts showed excellent cytocompatibility, supporting cell growth over 5 days. Ultimately, these elastomers synergize excellent electrospinnability with biomimetic mechanics, offering a highly effective strategy for developing small-diameter vascular prostheses.
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