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Updated: May 8, 2026
08:18
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Design, Optimization and Pharmacokinetic Profiling of BCS Class II Drug Loaded Oral Self Nanoemulsifying System
Ayon Dutta1,2, Swarupananda Mukherjee3, Biswajit Basu4
1Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Delhi Road, Hooghly, 712102, West Bengal, India.
AAPS Pharmscitech
|May 6, 2026
Summary
This study developed Nicardipine loaded self nano emulsifying tablets (SNET) for hypertension. The SNET formulation demonstrated sustained drug release and significantly reduced blood pressure in rats, enhancing bioavailability.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Self nano emulsifying drug delivery systems (SNEDDS) offer improved oral bioavailability for poorly soluble drugs.
- Nicardipine (NIC) is a calcium channel blocker used for hypertension, but its oral delivery can be challenging.
Purpose of the Study:
- To develop and optimize Nicardipine-loaded liquid SNEDDS using Box-Behnken design.
- To formulate the optimized SNEDDS into self nano emulsifying tablets (SNET) for sustained drug release.
- To evaluate the in vivo pharmacokinetic and pharmacodynamic profile of the Nicardipine SNET (NT).
Main Methods:
- Liquid SNEDDS were developed and optimized using Box-Behnken design.
- Physicochemical characterization, DSC, and stability studies were performed.
- In vivo pharmacokinetic and pharmacodynamic studies were conducted in rats.
Main Results:
- Optimized SNEDDS exhibited a droplet size of 75.62 nm and rapid self-emulsification.
- The SNET formulation showed sustained drug release following Higuchi kinetics.
- NT treatment significantly reduced systolic blood pressure for 48 hours and enhanced NIC bioavailability compared to pure drug suspension.
Conclusions:
- The developed Nicardipine SNET is a promising formulation for sustained hypertension management.
- The SNEDDS approach effectively enhances Nicardipine's oral bioavailability and therapeutic efficacy.
- This formulation offers a potential alternative for improving patient compliance and treatment outcomes in hypertension.
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