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Updated: May 8, 2026

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

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Optimizing Parathyroid Localization in Real Life: The Role of Expert-Performed Ultrasonography.

Tzahi Yamin^1,2, Nir Battat³, Annat Blank³

¹Department of Otolaryngology and Head and Neck Surgery, Samson Assuta University Hospital, Ashdod, Israel.

Clinical Endocrinology

|May 6, 2026

Summary

Expert ultrasonography (US) is highly accurate for preoperative localization in minimally invasive parathyroidectomy (MIP), outperforming other imaging methods. Surgeons should prioritize expert US, especially for complex cases like ectopic adenomas or multiglandular disease.

Keywords:

hyperparathyroidism localization minimally invasive parathyroid adenoma ultrasonography

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Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

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Last Updated: May 8, 2026

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

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Published on: February 9, 2024

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Area of Science:

Endocrinology
Radiology
Surgical Oncology

Background:

Minimally invasive parathyroidectomy (MIP) relies on accurate preoperative localization of parathyroid adenomas.
Current imaging modalities vary in diagnostic accuracy, impacting surgical outcomes.

Purpose of the Study:

To compare the diagnostic accuracy of expert-performed ultrasonography (US) against community US and other imaging techniques for preoperative parathyroid adenoma localization.
To evaluate the utility of expert US in complex cases, including ectopic adenomas and multiglandular disease.

Main Methods:

Retrospective diagnostic accuracy study of 227 patients with primary hyperparathyroidism.
Preoperative imaging included expert US, community US, 99mTc-MIBI, SPECT-CT, and 4D-CT.
Sensitivity, specificity, and positive predictive value (PPV) were calculated and compared.

Main Results:

Expert US demonstrated high sensitivity (89%), specificity (98%), and PPV (95%), accurately localizing adenomas in 89% of cases.
Expert US significantly outperformed community US, MIBI, SPECT-CT, and 4D-CT in sensitivity and specificity.
Superior performance was noted in atypical cases, such as ectopic adenomas (25% prevalence) and multiglandular disease (6% prevalence).

Conclusions:

Expert-performed US is a highly accurate primary imaging modality for guiding MIP.
Referral to an expert ultrasonographer is recommended for suspected ectopic adenomas, multiglandular disease, or before considering 4D-CT or bilateral neck exploration.