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Putative Clonal Evolution in a PHF6-Mutant T/NK-Cell Lymphoproliferative Disorder With Selective Loss of a

Mark Anthony Turingan1, Cuihong Wei2, Nihad Almokhtar3

  • 1Department of Laboratory Hematology and Laboratory Medicine University Health Network University of Toronto Toronto Canada.

Ejhaem
|May 7, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
PHF6STAT5B N642HT/NK‐cell lymphoproliferative disorderclonal evolutionperipheral T‐cell lymphoma, NOSsubclonal divergence

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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