Related Experiment Video

Updated: May 12, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

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Correlation of C1q/tumor necrosis factor-related protein 1 with left ventricular hypertrophy in essential

Shuya Tian1, Xinyu Wang2

  • 1Department of Geriatrics, Shandong Provincial Third Hospital, Shandong University, Jinan, China.

Blood Pressure
|May 10, 2026
PubMed

Insights

Complement C1q/tumor necrosis factor-related protein 1 (CTRP1) is linked to left ventricular hypertrophy (LVH) in hypertension patients. Higher CTRP1 levels correlate with increased LVH severity and inflammation.

Area of Science:

  • Cardiology
  • Endocrinology
  • Hypertension Research

Background:

  • Left ventricular hypertrophy (LVH) is a significant complication of hypertension, increasing morbidity and mortality.
  • The complex pathophysiology of LVH involves proinflammatory and profibrotic factors.
  • Complement C1q/tumor necrosis factor-related protein 1 (CTRP1), an adipokine, is implicated in adverse cardiometabolic changes.

Purpose of the Study:

  • To investigate the association between CTRP1 and LVH in patients diagnosed with essential hypertension.
  • To determine if CTRP1 levels correlate with the severity of cardiac hypertrophy and inflammation in hypertensive individuals.

Main Methods:

  • 360 patients with essential hypertension were categorized into groups with and without LVH.
  • Plasma levels of CTRP1, adiponectin, and IL-6 were quantified using ELISA.
  • Left ventricular mass index (LVMI) was assessed via echocardiography; subgroup analyses were performed based on sex and CTRP1 tertiles.

Main Results:

  • Patients with LVH exhibited elevated CTRP1, IL-6, and LVMI, alongside reduced adiponectin levels compared to controls.
  • CTRP1 levels showed a positive correlation with LVMI in both sexes.
  • Higher CTRP1 tertiles were associated with increased systolic blood pressure (SBP), diastolic blood pressure (DBP), C-reactive protein (CRP), IL-6, and LVMI.

Conclusions:

  • CTRP1 is an independent factor associated with LVH in essential hypertension.
  • A dose-response relationship exists between CTRP1, cardiac hypertrophy, and inflammatory markers.
  • CTRP1 may play a crucial role in the development and progression of LVH in hypertensive patients.
Abstract

Keywords:
CTRP1adipocytokinesbiomarkerhypertensionleft ventricular hypertrophy

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