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Updated: May 12, 2026

In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model
Published on: November 17, 2018
Size-tunable hemoglobin oxygen carriers with antioxidant and pro-angiogenic functions for wound healing
Yu Zhang1, Honglei Zhu1, Qinqi Wang1
1School o Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun, 130022, China. lileijiao@cust.edu.cn.
Abstract:
Size-tunable hemoglobin-based oxygen carriers (Hb-Oxy) were synthesized via a template-assisted strategy and functionalized with caffeic acid (CA). The optimized Hb-CA building blocks exhibit an ideal P50 (35.84 mmHg) and >99% radical scavenging efficiency. Both micro-sized (L-Hb-CA) and nano-sized (S-Hb-CA) carriers constructed from these blocks retain excellent subunit cooperativity (Hill coefficient ∼2.66), synergistically promoting wound healing (>97% closure in 10 days) by mitigating hypoxia and inflammation.
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