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Serum Phospholipase A2 Receptor Antibody Is Associated with Thrombogenesis in Primary Membranous Nephropathy: A

Paula Dibo1, Henrique Alexsander Ferreira Neves2, Raghunandan Konda3

  • 1Division of General Internal Medicine, Department of Medicine, Emory University, AtlantaGA, USA.

Glomerular Diseases
|May 11, 2026
PubMed
Abstract

Insights

The anti-serum phospholipase A2 receptor antibody (anti-PLA2R Ab) is linked to a higher risk of thromboembolism in primary membranous nephropathy (PMN) patients. This finding supports anti-PLA2R Ab as a potential biomarker for thrombogenesis in PMN.

Area of Science:

  • Nephrology
  • Immunology
  • Thrombosis

Background:

  • Primary membranous nephropathy (PMN) is a major cause of nephrotic syndrome in adults.
  • PMN is associated with an elevated risk of thromboembolic events.
  • The anti-serum phospholipase A2 receptor antibody (anti-PLA2R Ab) is specific to PMN and may promote a prothrombotic state.

Purpose of the Study:

  • To systematically review and meta-analyze the association between serum anti-PLA2R Ab and thromboembolic events in PMN patients.
  • To investigate the potential of anti-PLA2R Ab as a biomarker for thrombogenesis.

Main Methods:

  • Systematic search of PubMed, Embase, and Cochrane databases.
  • Inclusion of seven studies with 1,162 PMN patients.
  • Pooled analysis of odds ratios (ORs) and mean differences with 95% confidence intervals (CIs); heterogeneity assessed using I² statistics.

Main Results:

  • Patients with anti-PLA2R Ab had significantly higher odds of thromboembolism (OR 1.52; 95% CI 1.10, 2.09; p = 0.01).
  • Thromboembolism was associated with lower serum albumin (p = 0.003) but not proteinuria or age.
  • Higher total cholesterol levels were observed in anti-PLA2R Ab-positive patients (p < 0.0001).

Conclusions:

  • A significant association exists between anti-PLA2R Ab presence and thromboembolism risk in PMN.
  • Anti-PLA2R Ab may serve as a valuable biomarker for predicting thrombogenesis in PMN patients.
Keywords:
CreatinineGlomerular filtration ratePrimary membranous nephropathyProteinuriaSerum albuminSerum phospholipase A2 receptor antibodiesThromboembolismThrombogenesisTotal cholesterol

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