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Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
Published on: July 17, 2018
Adipose-Derived Stem Cells From Human Lumbar Subcutaneous Tissue in Obesity: Inflammatory Microenvironment Promotes
Yining Zhang1, Shengwu Yu2, Yanwen Chen3
1Department of Laboratory Medicine, Ningbo Hangzhou Bay Hospital, Ningbo Branch of Renji Hospital, Shanghai Jiao Tong University School of Medicine, Ningbo, Zhejiang, China, shsmu.edu.cn.
Stem Cells International
|May 11, 2026
Summary
Adipose-derived stem cells (ADSCs) from obese individuals show enhanced differentiation potential, possibly due to inflammation. This finding offers new strategies for stem cell therapies.
Area of Science:
- Stem cell biology
- Regenerative medicine
- Obesity research
Background:
- Adipose-derived stem cells (ADSCs) are promising for clinical therapy.
- Obesity may alter ADSC characteristics compared to normal-weight individuals.
Purpose of the Study:
- Compare ADSCs from obese vs. normal-weight donors.
- Investigate the impact of an inflammatory environment on ADSCs.
Main Methods:
- Isolated ADSCs from normal (N) and obese (O) donors.
- Assessed proliferation, phenotype, and differentiation.
- Prestimulated Group N ADSCs with cytokines (Group Pre) to mimic obesity.
- Performed proteomic analysis on conditioned media.
Main Results:
- Group O ADSCs had lower proliferation but higher differentiation potential than Group N.
- Group Pre ADSCs showed enhanced differentiation and stemness markers compared to Group N.
- Proteomics revealed altered metabolism and inflammatory/immune responses in Group O ADSCs.
Conclusions:
- Obese individuals' ADSCs may have superior differentiation potential.
- Inflammation in obese adipose tissue may drive these enhanced stem cell properties.
- Findings suggest novel strategies for autologous stem cell therapies.
