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Electroacupuncture-Induced Phrenic Nerve Stimulation for Poststroke Pneumonia: A Propensity Score Matching Analysis.

Bing-Feng Xing¹, Xiao-Qiang Huang¹, Hua Zhong²

¹Department of Integrated Traditional Chinese and Western Medicine for Metabolic Diseases, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China, gdpu.edu.cn.

Biomed Research International

|May 11, 2026

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Electroacupuncture (EA) significantly improved poststroke pneumonia (PSP) outcomes by enhancing diaphragmatic activity. This treatment reduced infection severity and inflammatory markers in bedridden patients with speech dysfunction.

Area of Science:

Neurology
Pulmonology
Integrative Medicine

Background:

Poststroke pneumonia (PSP) is a frequent complication in bedridden patients with speech dysfunction, often leading to adverse outcomes.
This study investigates electroacupuncture (EA) as a potential treatment for PSP by targeting phrenic nerve stimulation.

Purpose of the Study:

To evaluate the clinical efficacy of electroacupuncture (EA) in treating poststroke pneumonia (PSP).
To assess EA's impact on diaphragmatic activity and inflammatory markers in PSP patients.

Main Methods:

A retrospective cohort study involving 88 hospitalized poststroke pneumonia patients.
Patients received either standard treatment or standard treatment plus EA targeting the phrenic nerve.
Propensity score matching (PSM) was used, resulting in 22 exposed and 29 nonexposed patients for analysis over 2 weeks.

Keywords:

diaphragmatic activity electroacupuncture phrenic nerve pneumonia stroke

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Main Results:

The EA group showed significant reductions in Clinical Pulmonary Infection Score (CPIS) and inflammatory markers (WBC, CRP, IL-6, PCT) compared to the control group.
Post-PSM analysis revealed a greater absolute reduction in CPIS scores in the EA group (-2.32 vs. -1.00).
EA significantly improved diaphragmatic activity and excursion (approx. 0.32 cm increase) within 10 days.

Conclusions:

Electroacupuncture may improve ventilation and sputum clearance by enhancing diaphragmatic activity via phrenic nerve stimulation.
EA demonstrates potential as an effective adjunctive therapy for managing poststroke pneumonia.