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NIR-II fluorescence projection technology for augmented-reality surgical navigation.

Yuhuang Zhang¹, Xiaolong Liu², Zihang Liu¹

¹State Key Laboratory of Extreme Photonics and Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, Hangzhou 310058, China.

National Science Review

|May 14, 2026

Summary

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This summary is machine-generated.

This study introduces a novel co-axial near-infrared-II (NIR-II) fluorescence projection system for surgical navigation. The system enhances visualization by projecting images directly onto the surgical field, reducing surgeon distraction and improving workflow.

Area of Science:

Biomedical Optics
Surgical Technology
Medical Imaging

Background:

Near-infrared-II (NIR-II) fluorescence imaging offers superior tissue penetration for surgical guidance.
Current clinical use is limited by workflow issues, requiring surgeons to switch visual focus between the operative field and external monitors.
This visual switching increases cognitive load and disrupts surgical procedures.

Purpose of the Study:

To develop and validate a novel co-axial NIR-II fluorescence projection navigation system.
To enable real-time, in situ visualization of fluorescence signals directly within the surgical field.
To address the workflow limitations of current NIR-II imaging modalities in surgical navigation.

Main Methods:

Development of a co-axial projection system for NIR-II fluorescence imaging.

Keywords:

NIR-II fluorescence clinical trials projection technology surgical navigation

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Integration of high-precision, pseudocolored fluorescence image projection onto the surgical field.

Validation through in vitro, in vivo, and clinical patient studies.

Main Results:

The system provides real-time, in situ augmented reality visualization.
Eliminates the need for visual field switching between the operative site and monitors.
Demonstrated reduction in intraoperative distraction and preservation of natural stereoscopic vision.
Successful validation in diverse study settings, including clinical patients.

Conclusions:

The co-axial NIR-II fluorescence projection system offers a paradigm shift in surgical navigation.
It creates a more coherent, efficient, and ergonomically optimized optical imaging modality.
This technology has the potential to significantly enhance surgical precision and safety.