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Updated: May 15, 2026

Knee Arthrocentesis in Adults

Knee Arthrocentesis in Adults

Published on: February 25, 2022

EVALUATION OF THE RADIOISOTOPIC SYNOVECTOMY PROTOCOL IN PATIENTS WITH HEMOPHILIA.

Marcela Dos Santos Martins¹, Janaina Bosso da Silva Ricciardi¹, Allan de Oliveira Santos¹

¹Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciencias Medicas, Sao Paulo, SP, Brazil.

Acta Ortopedica Brasileira

|May 14, 2026

Summary

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Radioisotopic synovectomy (RS) significantly reduced bleeding events in hemophilia patients by 44.68%. This safe and effective procedure offers a valuable treatment option for managing hemophilic arthropathy and preventing joint destruction.

Area of Science:

Orthopedics
Hematology
Nuclear Medicine

Background:

Hemophilia commonly causes intra-articular hemorrhage, leading to chronic synovitis and joint destruction.
Conservative treatments may fail to halt synovitis progression in hemophilic arthropathy.
Radioisotopic synovectomy (RS) is a treatment option to interrupt joint destruction by removing inflamed synovium.

Purpose of the Study:

To evaluate the safety and effectiveness of radioisotopic synovectomy (RS) in reducing hemarthrosis incidence.
To assess the impact of RS on bleeding events in hemophilia patients.

Main Methods:

Retrospective study analyzing medical records of patients undergoing RS.
Comparison of bleeding event frequency one year before and one year after RS.

Keywords:

Hemophilia Joint diseases Radioisotopes Synovectomy

Related Experiment Videos

Last Updated: May 15, 2026

Knee Arthrocentesis in Adults

Knee Arthrocentesis in Adults

Published on: February 25, 2022

Statistical analysis using the Wilcoxon signed-rank test.

Main Results:

65 RS procedures were performed between 2008 and 2018.
A significant reduction in bleeding events from 367 to 203 (44.68% decrease, P<0.001) was observed post-RS.
No procedure-related complications were reported.

Conclusions:

Radioisotopic synovectomy (RS) is a safe and effective treatment for reducing bleeding events in hemophilia patients.
RS can help manage chronic synovitis and prevent further joint damage in hemophilic arthropathy.
The study supports RS as a valuable therapeutic option for hemophilia management.