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Updated: May 16, 2026
08:25
Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice
Published on: July 16, 2014
Challenges in Brain Drug Delivery for Neurodegenerative Disorders and Recent Trends: A Review
Ashif Anjukandan1, Rajaganapathy Kaliyaperumal2
1Faculty of Pharmacy, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
CNS & Neurological Disorders Drug Targets
|May 15, 2026
Summary
Novel drug delivery systems are crucial for treating neurodegenerative disorders, overcoming the blood-brain barrier (BBB) challenge. This review explores advanced strategies for effective targeted drug therapy in the brain.
Area of Science:
- Neuroscience
- Pharmacology
- Biomedical Engineering
Background:
- Neurodegenerative disorders involve progressive neuronal loss, impacting brain function across all age groups.
- Dementias and motor system impairments characterize many neurodegenerative diseases.
- The blood-brain barrier (BBB) presents a significant obstacle for effective drug delivery to the brain.
Purpose of the Study:
- To review neurodegenerative disorders and their impact.
- To discuss the anatomical and physiological challenges of drug delivery across the BBB.
- To explore novel drug delivery systems and targeted therapies for neurological conditions.
Main Methods:
- A critical literature review was performed using Scopus, Embase, Cochrane, and PubMed.
- Search terms included "blood-brain barrier," "neurodegenerative disorders," "novel drug delivery system," and "targeted drug therapy."
Main Results:
- Neurodegenerative Diseases (NDD) affect the nervous system, muscles, and nerve-muscle junctions, encompassing conditions like Alzheimer's and Parkinson's disease.
- Conventional treatments for neurological diseases have limited efficacy due to the BBB's restrictive nature.
- Effective brain drug delivery strategies include nanocarrier systems, intranasal administration, and focused ultrasound.
Conclusions:
- This review synthesizes information on neurodegenerative disorders.
- It highlights the critical role of the BBB in limiting therapeutic interventions.
- It discusses innovative strategies to overcome drug delivery barriers for improved neurological treatment.
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