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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Relationship between periodontitis and oral cancer: A Mendelian randomization study
Sreeraj Rajappan1, Neethu P Reghu2, Shilpa Mathew1
1Department of Periodontics, Government Dental College, Alappuzha, Kerala, India.
None:
Previous observational studies have found a positive association between periodontitis and oral cancer; however, the causal role of periodontitis in oral cancer has not yet been determined. Mendelian randomization (MR) studies are considered superior to traditional observational studies for causal inferences. Therefore, it is of interest to examine the potential causal link between periodontitis and oral cancers using MR analysis. Data were retrieved from the NHGRI-EBI GWAS Catalogue within MR-Base using the "TwoSampleMR" R package. The analysis employed the inverse variance method, with sensitivity analysis using MR-Egger, weighted median and mode approaches. MR analysis showed no association between periodontitis and oral cancer. However, aggressive periodontitis showed significance (p = 0.001), with an odds ratio of 1.39 (95% CI: 1.14-1.69), indicating causality.
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