Related Experiment Video
Updated: May 19, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Urinary NGAL and NGAL/creatinine as tubular biomarkers in type 2 diabetes
Prabhat Kumar Singh1, Anand Vishal1, Kirandeep Kamal2
1Department of Medicine, ABVIMS and Dr. RML Hospital, New Delhi, India.
Abstract:
Diabetic kidney disease (DKD) screening based on albuminuria and creatinine-derived eGFR may miss early tubular injury and normoalbuminuric renal impairment. Therefore, it is of interest to evaluate urinary neutrophil gelatinase-associated lipocalin (NGAL) and NGAL/creatinine ratio (NGAL/Cr) as complementary biomarkers in 70 patients with type 2 diabetes and 70 controls. NGAL and NGAL/Cr were higher in diabetes, correlated positively with albuminuria and inversely with eGFR and showed strong ROC discrimination for albuminuria. Urinary NGAL and NGAL/Cr may complement albuminuria and eGFR for early detection and risk stratification of DKD.
Related Concept Videos
Diabetic Nephropathy
Urine Studies I: Urinalysis
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
Serum Studies: Renal Function Tests
Diabetes Mellitus: Type 2 and Gestational
