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Related Concept Videos

Mechanism of Conjugation01:19

Mechanism of Conjugation

Bacterial conjugation is a mechanism of horizontal gene transfer that enables the exchange of genetic material between bacterial cells through direct contact. This process is facilitated by a donor cell carrying a conjugative plasmid, which encodes genes necessary for pilus formation, DNA replication, and transfer. The conjugative plasmid plays a central role in initiating and executing the transfer of genetic material.The tra region of the conjugative plasmid encodes proteins responsible for...
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Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
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Amphiphilic Lipid-Single-Stranded DNA Conjugate-Mediated Cell Surface Engineering for Programmable Intercellular

Sungjun Kim1, Chae Eun Lee2, Ashok Kumar Jangid2

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|May 18, 2026
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Researchers engineered cell surfaces using DNA to enhance immune cell interactions, improving cancer cell killing. This novel approach offers a versatile platform for immunotherapy and tissue engineering applications.

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Area of Science:

  • Biotechnology
  • Immunology
  • Materials Science

Background:

  • Solid tumors present physical constraints limiting effective immune cell interactions and sustained engagement.
  • Natural killer (NK) cell activation relies on stable immune synapses, often hindered by antigen heterogeneity and immune escape.
  • Current strategies targeting tumor antigens are vulnerable to tumor evolution and immune evasion.

Purpose of the Study:

  • To develop a controllable, receptor-independent method for regulating intercellular interfaces using DNA nanotechnology.
  • To engineer cell surfaces to enhance effector-target cell engagement and immune synapse formation.
  • To investigate the efficacy of this platform in disrupting solid tumors and facilitating NK cell-mediated cytotoxicity.

Main Methods:

  • Utilized amphiphilic single-stranded DNA (ssDNA) constructs conjugated with lipids for cell membrane anchoring.
  • Engineered sequence-specific cell association via DNA hybridization for controlled tethering.
  • Developed thermally reversible ssDNA interactions for tunable dissociation of tethered cell pairs.
  • Validated the platform's effectiveness in 2D cell cultures and 3D tumoroid models.

Main Results:

  • Rapid and effective cell membrane modification was achieved with the ssDNA constructs.
  • Complementary ssDNA pairing significantly enhanced effector-target cell tethering and stability.
  • Increased secretion of cytotoxic granules and cytokines was observed, boosting anti-tumor activity.
  • Demonstrated successful NK cell-mediated disruption of triple-negative breast cancer cells in 3D models.

Conclusions:

  • Engineering intercellular physical properties via programmable ssDNA platforms can actively modulate immune synapse efficiency.
  • This ssDNA-based surface engineering strategy provides a versatile framework for regulating cell-cell interfaces.
  • The platform shows broad applicability in immunotherapy, tissue engineering, and cell-based therapeutics.