Mild 18 F-PSMA-1007 Uptake in a Giant Bone Island

Area of Science:

• Radiology
• Nuclear Medicine
• Orthopedic Oncology

Background:

• Giant bone islands, defined as bone islands with a diameter greater than 2.0 cm, are uncommon findings.
• Bone islands are typically benign, asymptomatic, and radiographically characterized by well-defined sclerotic lesions.

Purpose of the Study:

• To describe the 18F-PSMA-1007 Positron Emission Tomography/Computed Tomography (PET/CT) findings in a patient with a giant bone island.
• To evaluate the potential role of 18F-PSMA-1007 uptake in characterizing giant bone islands and its association with osteoblastic activity.

Main Methods:

• A case report detailing the imaging findings in a patient with a giant bone island.
• Utilized 18F-PSMA-1007 PET/CT to visualize and assess the metabolic activity of the giant bone island.
• Standard Computed Tomography (CT) was used to determine the size and morphology of the lesion.

Main Results:

• The giant bone island was located in the left femoral head and measured 2.2 cm in maximum diameter on CT.
• The lesion appeared as a well-defined sclerotic lesion.
• Mild 18F-PSMA-1007 uptake was observed in the giant bone island on PET imaging.

Conclusions:

• 18F-PSMA-1007 PET/CT can visualize giant bone islands.
• Mild 18F-PSMA-1007 uptake in a giant bone island may indicate underlying osteoblastic activity.
• Further research is warranted to understand the implications of PSMA expression in benign bone lesions.