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No-wash immunosensors based on superhydrophilic covalent organic framework nanosheets with aggregation-induced
Yue Du1, Meiling Ye1, Wentao Xu1
1Nanofiber Engineering Center of Jiangxi Province, National Engineering Research Center for Carbohydrate Synthesis, Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education, College of Chemistry and Materials of Jiangxi Normal University, 99 Ziyang Road, Nanchang 330022, China. lwang@jxnu.edu.cn.
Abstract:
Enhancing the aggregation-induced emission (AIE) activity and hydrophilicity of AIE-covalent organic framework nanosheets (CONs) is important for improving the sensitivity of sandwich-type fluorescence-on immunosensors. This work developed 2,2',2″,2‴-(ethene-1,1,2,2-tetrayltetrakis([1,1'-biphenyl]-4',4-diyl))tetraacetonitrile-based AIE-CONs containing cyano and hydroxyl groups with high AIE activity and hydrophilicity to construct a highly sensitive immunosensor for detecting carbohydrate antigen 19-9.
