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(Hybrid) SPECT and PET Technologies.

Teresa Lemainque1, Nicolas Gross-Weege2, Volkmar Schulz3

  • 1Chair of Diagnostic and Interventional Radiology, University Clinic RWTH Aachen, Aachen, Germany.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|May 18, 2026
PubMed
Summary
This summary is machine-generated.

Hybrid imaging combines functional nuclear imaging (SPECT/PET) with anatomical imaging (CT/MRI) to overcome limitations. This chapter explores SPECT and PET physics, detector technologies, hybrid concepts, challenges, current systems, AI, and future developments.

Keywords:
Artificial intelligenceAttenuation correctionDetector technologyHybrid imagingImage reconstructionPET-CTPET-MRISPECT-CTSPECT-MRI

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Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Biophysics

Background:

  • Single-photon emission computed tomography (SPECT) and positron emission tomography (PET) provide functional imaging but lack anatomical detail.
  • Combining SPECT/PET with anatomical modalities like CT or MRI enhances diagnostic accuracy.
  • This integration addresses the inherent limitations of standalone nuclear imaging techniques.

Purpose of the Study:

  • To provide a comprehensive overview of hybrid SPECT and PET imaging.
  • To discuss the underlying physics, detector technologies, and hybrid imaging principles.
  • To explore the challenges, current systems, and future advancements in hybrid nuclear imaging.

Main Methods:

  • Review of fundamental physics principles of SPECT and PET.
  • Presentation of detector technologies, requirements, and concepts.
  • Introduction to hybrid imaging concepts and challenges, particularly with MRI.

Main Results:

  • Detailed explanation of SPECT and PET physics and detector technologies.
  • Discussion of hybrid imaging principles and challenges, including MRI interference and attenuation correction.
  • Overview of current clinical and preclinical hybrid systems and emerging technologies like total body PET-CT.

Conclusions:

  • Hybrid imaging significantly improves diagnostic capabilities by integrating functional and anatomical information.
  • Technological advancements, including AI, are crucial for overcoming challenges and optimizing hybrid imaging systems.
  • Future developments promise further enhancements in hybrid SPECT and PET technology for clinical and preclinical applications.