Related Experiment Video

Updated: May 20, 2026

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
08:58

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

Directed interactions between electrophysiological, vascular, and fluid dynamics in the sleeping brain

Haatef Pourmotabbed1,2,3, Catie Chang1,2,3,4,5

  • 1Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235.

Proceedings of the National Academy of Sciences of the United States of America
|May 18, 2026
PubMed
Summary

No abstract available in PubMed .

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Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
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Sleep-Wake Cycles01:24

Sleep-Wake Cycles

Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Stages of Sleep01:22

Stages of Sleep

Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...

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