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Stromal-only endometriosis catamenial pneumothorax: A diagnostic algorithm with potential pitfalls
Riccardo Papa1, Alberto Meroni2, Matteo Incarbone3
1Inter-hospital Pathology Division, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), MultiMedica, Via G. Fantoli 16/15, Milan, 20138, Italy.
Summary
Catamenial pneumothorax (CP), a rare condition linked to thoracic endometriosis, often affects the right side. Diagnosing stromal-only endometriosis causing CP can be challenging, requiring careful clinicopathologic correlation.
Area of Science:
- Reproductive Medicine
- Thoracic Surgery
- Pathology
Background:
- Catamenial pneumothorax (CP) is a rare recurrent spontaneous pneumothorax linked to thoracic endometriosis.
- It predominantly affects the right hemithorax, possibly due to transdiaphragmatic endometrial tissue migration.
- Diagnosis is difficult with gland-deficient stromal-only endometriosis.
Purpose of the Study:
- To describe two challenging cases of recurrent right-sided pneumothorax due to stromal-only endometriosis.
- To propose a diagnostic flowchart for gland-deficient thoracic endometriosis.
- To emphasize clinicopathologic correlation in diagnosing difficult CP cases.
Main Methods:
- Case report analysis of two patients with recurrent pneumothorax.
- Histopathological review of endometrial deposits.
- Development of a diagnostic flowchart.
Main Results:
- Two cases of recurrent right-sided pneumothorax were identified.
- Paucifocal endometrial deposits consistent with stromal-only endometriosis were found.
- Diagnostic challenges were noted due to the absence of endometrial glands.
Conclusions:
- Stromal-only endometriosis can cause challenging cases of catamenial pneumothorax.
- A diagnostic flowchart can aid in recognizing gland-deficient thoracic endometriosis.
- Close clinicopathologic correlation is crucial for accurate diagnosis.
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