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Updated: May 21, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
[Mild traumatic brain injury : practical management in general practice]
Tiffany Zahnd1, Nguyen Toan Tran2,3, Baptiste Pedrazzini2
1Policlinique de médecine générale, Département des policliniques, Centre universitaire de médecine générale et santé publique Unisanté, 1010 Lausanne.
Abstract:
Each year, more than 20,000 people sustain a traumatic brain injury in Switzerland. The vast majority of these are mild, with severe complications being rare and outcomes generally favorable. However, a minority of patients experience persistent, heterogeneous, and nonspecific symptoms that may be disabling. Management relies on a patient-centered approach combining information, reassurance, management of the predominant symptoms, and gradual return to activities. Early identification of risk factors for chronicity helps to identify patients at risk for an unfavorable course. Appropriate clinical follow-up may limit the progression to severe forms requiring interdisciplinary and specialized care, thereby improving prognosis while reducing the risk of overmedicalization.
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