Catalytic and Antitubercular Activities of Multifunctional Copper(II)-Schiff Base Complexes: Insights into Structure,
Anna Jurowska1, Weronika Bogdał1, Janusz Szklarzewicz1
1Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków 30-387, Poland.
Abstract:
Three copper(II) complexes featuring tridentate ONO donor Schiff base ligands were synthesized and thoroughly characterized by X-ray crystallography, spectroscopy, and electrochemical methods. Density functional theory (DFT) calculations provided insights into their electronic structures and ligand-metal interactions. Complex 1 exhibited moderate catalytic activity toward the selective oxidation of toluene and styrene under mild conditions. Biological assays demonstrated measurable antimycobacterial effects against drug-sensitive and -resistant Mycobacterium tuberculosis strains, while combination studies with standard anti-TB drugs revealed mainly additive or indifferent interactions. These results highlight the promise of these copper(II) Schiff-base complexes as multifunctional agents with catalytic and therapeutic applications.
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