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Related Concept Videos

Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...

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Related Experiment Video

Updated: May 22, 2026

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
07:27

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy

Published on: May 13, 2012

Modeling cell migratory persistence through temporal correlations and angular noise.

Ignacio Montenegro-Rojas1, Martín Andaur-Lobos1, Karol Soler-Orozco1

  • 1Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.

Plos One
|May 20, 2026
PubMed
Summary
This summary is machine-generated.

Cell migration persistence is crucial for development and disease. Our model shows correlated noise, mimicking cellular memory, enhances directional cell movement and adaptability.

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Related Experiment Videos

Last Updated: May 22, 2026

Quantitative Analysis of Random Migration of Cells Using Time-lapse Video Microscopy
07:27

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Published on: May 13, 2012

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

Analysis of Cell Migration within a Three-dimensional Collagen Matrix
08:02

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

Area of Science:

  • Biophysics
  • Computational Biology
  • Cell Biology

Background:

  • Cell migration persistence is vital for biological processes like development and cancer invasion.
  • Existing models often overlook temporal correlations in cell polarity and protrusion dynamics.
  • Understanding these correlations is key to explaining complex cell movement.

Purpose of the Study:

  • To develop a novel agent-based model incorporating temporal correlations in cell migration.
  • To investigate the role of correlated noise and angular reorientation in cell trajectory dynamics.
  • To explore emergent behaviors in cell migration, especially under chemotaxis.

Main Methods:

  • Developed an agent-based model using stochastic differential equations.
  • Integrated fractional Brownian motion to simulate translational autocorrelation.
  • Simulated cell migration by varying angular reorientation and correlated noise strength.

Main Results:

  • Temporal correlation stabilizes cell trajectories and enhances persistence, even with significant angular reorientation.
  • Correlated noise, unlike white noise, markedly improves migration persistence.
  • Combined effects of correlated noise and taxis lead to emergent behaviors, tuning persistence and responsiveness.

Conclusions:

  • Correlated noise acts as a computational proxy for intrinsic cellular memory.
  • The model provides a flexible framework for analyzing diverse cell migration patterns.
  • This approach deepens understanding of the mechanisms underlying persistent cell movement.