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Recent advances in Epstein-Barr virus vaccines development from mechanistic exploration to clinical translation
Liwei Hong1, Juju Zhou1, Junjuan Tan1
1Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Abstract:
Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus linked to malignancies and autoimmune diseases. No licensed vaccines are currently available. Recent advances in EBV biology have enabled rational antigen selection and accelerated development of multivalent vaccines using platforms such as mRNA and nanoparticles. This review outlines key mechanisms, vaccine targets, and platform innovations, and discusses major challenges and future directions for EBV vaccine development.
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