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Propofol-based total intravenous anesthesia and recurrence-free survival after hepatectomy-does it improve outcomes?

Ying Qiu Zhou1, Rodney A Gabriel1,2

  • 1Division of Perioperative Informatics, Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.

Annals of Translational Medicine
|May 21, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Hepatectomycancer recurrenceoncologic outcomessevofluranetotal intravenous anesthesia (TIVA)

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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.