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Genetic Uncertainties Fueling Cholangiocarcinoma Progression

Sunil Kumar Kadiri1, Prashant Tiwari1

  • 1Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, Deverakeggahali, Kanakapura Road, Ramanagara Dist. Karnataka - 562112, India.

Current Genomics
|May 21, 2026
PubMed
Summary

Genetic mutations in IDH1/2, FGFR2, and KRAS drive aggressive intrahepatic cholangiocarcinoma (iCCA) liver cancer. Understanding these genetic changes and epigenetic factors is key for developing targeted therapies for iCCA.

Keywords:
Intrahepatic cholangiocarcinomaepigenetic alterationsgenomic researchmalignant transformationtreatment strategies

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