Related Experiment Video
Updated: May 22, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Published on: May 12, 2019
A rare case of urethral metastasis from colonic origin
Faiyaz Rahman1, Shravankrishna Ananthapadmanabhan1, Jeremy Saad1,2
1Nepean Urology Research Group, Nepean Hospital, Kingswood, New South Wales, Australia.
Abstract:
Secondary urethral tumours are rare, and metastasis from colorectal cancer is limited to a few case reports. Management is challenging given its rarity. We report the case of a 78-year-old male with colorectal adenocarcinoma presenting with lower urinary tract symptoms, with urethral metastasis identified during cystoscopy. Local clearance was achieved by cold cup biopsy supplemented by a multidisciplinary approach to overall patient care. This case highlights the need for thorough evaluation of new urinary symptoms in patients with a history of cancer, and the importance of multidisciplinary teams in managing rare cancers.
Related Concept Videos
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Ureters
Urinary Tract Calculi VI: Surgical Management
Urinary Tract Infection II: Pathophysiology
Diverticular Disease of the Colon
