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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Life's Essential 8-Defined Cardiovascular Health and Mortality Risk in Cardiovascular-Kidney-Metabolic Health Stages
Ruiyang Niu1,2, Qiqi You3, Wan Fu2
1College of Medicine, Hubei University of Arts and Science, Xiangyang, 441053, China.
Journal of Epidemiology and Global Health
|May 21, 2026
Summary
Improving cardiovascular health (CVH) significantly lowers mortality risk in cardiovascular-kidney-metabolic (CKM) syndrome stages 0-4. Nicotine exposure and blood glucose are key predictors of mortality.
Area of Science:
- Cardiovascular-kidney-metabolic (CKM) syndrome research
- Public health and epidemiology
- Biomedical science
Background:
- Cardiovascular-kidney-metabolic (CKM) syndrome is a major global health burden.
- The Life's Essential 8 (LE8) framework assesses cardiovascular health (CVH).
- The prognostic value of LE8-defined CVH in CKM syndrome is not well understood.
Purpose of the Study:
- To investigate the association between LE8-defined CVH and mortality risk.
- To examine this association across CKM health stages 0-4.
- To identify key CVH components influencing mortality.
Main Methods:
- Analysis of 302,171 UK Biobank participants across CKM health stages 0-4.
- Calculation of CVH scores based on eight LE8 components.
- Ascertainment of all-cause and cardiovascular disease (CVD) mortality via health records.
- Application of Cox proportional hazards models and gradient boosting machines.
Main Results:
- Higher CVH scores were linked to substantial reductions in all-cause (55%) and CVD (67%) mortality.
- The inverse association between CVH and CVD mortality was stronger in non-advanced CKM stages.
- Nicotine exposure and blood glucose scores demonstrated the highest influence on mortality prediction.
Conclusions:
- Elevated CVH scores are associated with reduced mortality risk across CKM health stages 0-4.
- Nicotine exposure and blood glucose are critical modifiable factors for mortality risk.
- CVH assessment holds potential for risk stratification in CKM syndrome.
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