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Updated: May 23, 2026
07:45
Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis
Published on: November 28, 2015
Macrophages in Psoriasis: From Functional Heterogeneity to Metabolic Reprogramming and Novel Therapeutics
Qianzi Liu1,2,3,4,5,6,7, Yexuan Wu8, Jinru Tang1,2,3,4,5,6,7
1The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Experimental Dermatology
|May 22, 2026
Summary
This review details macrophage heterogeneity and interactions in psoriasis, highlighting their role in skin inflammation. Macrophage-targeted therapies show promise for treating this complex skin condition.
Area of Science:
- Immunology
- Dermatology
- Cell Biology
Background:
- Psoriasis is a chronic inflammatory skin disease.
- Macrophages play a critical role in psoriasis pathogenesis.
- Understanding macrophage biology is key to developing new treatments.
Purpose of the Study:
- To provide a comprehensive overview of macrophage biology in psoriasis.
- To explore macrophage heterogeneity, polarization, and metabolic reprogramming.
- To examine multicellular interactions involving macrophages in psoriasis.
Main Methods:
- Review of single-cell technologies and omics data.
- Analysis of metabolic profiles in psoriasis macrophages.
- Integration of findings from spatial transcriptomics and metabolic studies.
Main Results:
- Single-cell technologies reveal diverse macrophage subsets in psoriasis.
- Macrophages exhibit distinct metabolic profiles and polarization states.
- Macrophages interact extensively with keratinocytes, immune cells, and other stromal cells.
Conclusions:
- Macrophages are central players in psoriasis development and progression.
- Targeting macrophage functions offers a promising therapeutic avenue.
- Emerging strategies include metabolic modulators and cell-based therapies.
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