Related Experiment Video
Updated: May 23, 2026
08:07
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
Identification of the Novel HLA-C*12:449 Allele During Routine Pre-Transplant HLA Typing
Hiteshree Buch1, Akshay Chaudhary1, Mahin Muhammed1
1Neuberg Centre for Genomics Medicine (NCGM), Neuberg Supratech Reference Laboratories (NSRL), Ahmadabad, Gujarat, India.
HLA
|May 22, 2026
Summary
A newly identified Human Leukocyte Antigen (HLA) allele, HLA-C*12:449, has been discovered. It differs from a known allele by a single genetic mutation in a key region.
Area of Science:
- Immunogenetics
- Molecular biology
- Human leukocyte antigen (HLA) system
Background:
- The Human Leukocyte Antigen (HLA) system plays a crucial role in immune response and transplantation.
- Genetic variations within HLA genes contribute to diverse immune profiles and disease susceptibility.
Purpose of the Study:
- To report the characterization of a novel HLA allele, HLA-C*12:449.
- To describe the specific genetic difference between HLA-C*12:449 and a previously identified allele.
Main Methods:
- Sequence analysis of the HLA-C gene.
- Comparison of nucleotide sequences to identify polymorphisms.
Main Results:
- A novel HLA allele, designated HLA-C*12:449, was identified.
- This new allele differs from HLA-C*12:02:02:01 by a single non-synonymous nucleotide substitution located in exon 7.
Conclusions:
- The discovery of HLA-C*12:449 expands the known diversity of the HLA-C locus.
- This finding may have implications for high-resolution HLA typing and population genetic studies.
