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Updated: May 23, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Structural Engineering of Furazanopyrazine Scaffolds with Flexible Biogenic Amines and Nitramine Moieties for Fused

Wei Du1,2, Weihua Zhu2, Jinshan Li1

  • 1National Key Laboratory of Chemical Explosion, Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang 621000, China.

Organic Letters
|May 22, 2026
PubMed

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The Hofmann and Curtius rearrangement reactions can be applied to synthesize primary amines from carboxylic acid derivatives such as amides and acyl azides. In the Hofmann rearrangement, a primary amide undergoes deprotonation in the presence of a base, followed by halogenation to generate an N-haloamide. A second proton abstraction produces a stabilized anionic species, which rearranges to an isocyanate intermediate via an alkyl group migration from the carbonyl carbon to the neighboring...
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